A major focus of the Group is to obtain novel understanding of the regulatory mechanisms in cell signaling through `systems-wide` investigations of signaling networks. In particular, we are interested in unraveling the properties and the regulatory landscape of posttranslational modifications (PTMs) in signaling networks. PTMs have crucial roles in the dynamic regulation of protein activity, stability, spatial localization, and communication with other macromolecules within cells. PTMs are directly relevant for human health as dysregulation of PTM-regulating enzymes, such as protein kinases, ubiquitin ligases, and lysine deacetylases, is frequently associated with human disease.

Our laboratory applies cutting-edge mass spectrometry-based proteomic technologies for unbiased, global, and quantitative analysis of key regulatory PTMs, such as lysine acetylation and ubiquitylation. The laboratory has state-of-the-art facilities for work related to cell biology, biochemistry, and genome editing, and has access to in-house infrastructure and expertise for live cell imaging, flow cytometry, the next generation nucleic acid sequencing, and protein biophysical analyses. The unique combination of the Group´s expertise and collaboration with leading researchers from Denmark and around the world distinctively positions the group to investigate the functional relevance of PTMs in diverse biological contexts.